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Study: Brain glucose stores open new horizons for Alzheimer’s treatment

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Brain glucose stores may play a more important role in the pathological relapse of neurons, which opens the way for new treatments for cases such as Alzheimer’s disease.

Alzheimer’s disease is a denial neurological disease characterized by the gradual deterioration of cognitive functions, such as memory, language, thinking, behavior and capabilities to solve problems. It is the most common cause of dementia, which represents 60-80 percent of cases. The vast majority of those with Alzheimer’s disease are elderly, although it also affects younger people who are less than 65 years old.

It is important to know that dementia refers to the general mental deterioration that contradicts daily functions, and Alzheimer’s disease is a form of dementia that relates to memory loss.

A new study mentioned important details by revealing important interactions between Alzheimer’s and glucose in its stored form of glycogen.

Under the leadership of the Pak Institute for Aging Research in the United States, this study has a new light on glycogen functions in the brain. Before that, it was only seen as a reserves for the energy of the liver and muscles.

“This new study challenges this opinion, and it has amazing effects,” says the molecular biology scientist, Kabahi, from the Pak Institute. He added: “The stored glycogen is not only found in the brain, but it is involved in pathology,” according to the website “Centr Ert”.

Based on the links that were previously found between glycogen and nervous degeneration, the researchers monitored evidence of excessive glycogen levels in each of the fruit flies cells (Drosovila Milagaster) and in the cells of the brain of Alzheimer’s patients.

The activity of glypine phosphoryllaise (Glyp) is an essential in this reaction, which is the main enzyme responsible for converting glycogen into fuel used by the body. When the researchers strengthened glycogen production in fruit flies, glycogen stores were used again, helping to fight cell damage.

“By increasing glycogen activity, brain cells can better remove harmful interactive oxygen types, which reduces damage,” says Sudaibta Bar, a biologist at the Back Institute.

The researchers explain if it is useful to follow a diet associated with improving brain health, when the phases of fruit infected with alto are placed on a low -protein diet, which lived for a longer period and showed less brain damage, indicating that the metabolic transformation resulting from a diet can help enhance glycogen.

These results are worth noting, not only because they indicate a way to treat glycogen and oo accumulation in the brain. The researchers also developed a drug based on a 8-br-Camp molecule to simulate the effects of food restriction, which had similar effects on flies in experiments.

This work may also be associated with research that includes GLP-1 receptors such as Ozmbek, designed to manage diabetes and reduce weight loss, which now also show promising results in dementia. The researchers note that this may be due to the interaction of these medications with one of the glycogen paths.

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