Bar-Peled, L. et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 340, 1100–1106 (2013).
Google Scholar
Chen, J. et al. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature 557, 585–589 (2018).
Google Scholar
Valenstein, M. L. et al. Nature https://doi.org/10.1038/s41586-024-07974-0 (2024).
Deng, L. et al. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Mol. Cell 58, 804–818 (2015).
Google Scholar
Cai, Y. et al. Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors. Cancer Res. 81, 2470–2480 (2021).
Google Scholar
Padi, S. K. R. et al. Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth. Proc. Natl Acad. Sci. USA 116, 20505–20510 (2019).
Google Scholar
Zhong, X. et al. Structural mechanisms for regulation of GSDMB pore-forming activity. Nature 616, 598–605 (2023).
Google Scholar
Oltra, S. S. et al. Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells. Cell Death Differ. 30, 1366–1381 (2023).
Google Scholar
Wolfson, R. L. et al. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature 543, 438–442 (2017).
Google Scholar
Khan, F. et al. Histidine affinity tags affect MSP142 structural stability and immunodominance in mice. Biotechnol. J. 7, 133–147 (2012).
Google Scholar
Rodriguez-Viciana, P. et al. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89, 457–467 (1997).
Google Scholar
Burchell, L., Chaugule, V. K. & Walden, H. Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation. PLoS ONE 7, e34748 (2012).
Google Scholar
Kong, X. et al. Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development. Development 149, dev201286 (2022).
Google Scholar
Xu, L. et al. Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARalpha pathway. Cell Death Dis. 12, 710 (2021).
Google Scholar
Linares, J. F. et al. K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Mol. Cell 51, 283–296 (2013).
Google Scholar
Jin, G. et al. Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1. Mol. Cell 58, 989–1000 (2015).
Google Scholar
Yao, Y. et al. Amino acids enhance polyubiquitination of Rheb and its binding to mTORC1 by blocking lysosomal ATXN3 deubiquitinase activity. Mol. Cell 80, 437–451 (2020).
Google Scholar
Jiang, C. et al. Ring domains are essential for GATOR2-dependent mTORC1 activation. Mol. Cell 83, 74–89 (2023).
Google Scholar
Hertel, A. et al. USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell Rep. 41, 111653 (2022).
Google Scholar
